Name: Common Name: Ginkgo Botanical Name: Ginkgo biloba L. Pharmaceutic Name: Semen Ginkgo; folium Ginkgo
Family: Ginkgoaceae
Parts Used: Seed, leaf
Sources
Ginkgo originally grew in China. In
1700s it was brought to Europe as decorative tree. During fall collect
their fruit when they are matured. After peel off the meat of the
fruit the seeds are the part to use. Instead, commercial ginkgo
extracts were made from the leaves. In Europe, Asia, and even the
United States, trees are specifically grown for producing extract.
Chemical Component
The seed contains starch, fat, protein,
Gibberellin, cytokinin-like substances. The exoderm contains ginkgolic
acid, hydroginkgolinic acid, bilobol, ginnol. The leaves contain
flavonoids and terpenoids. Ginkgo extracts sold in Europe are standardized
to contain 22-27 percent flavonoids and 5-7percent terpenoids.
Use Recommendations
Ginkgo leaf extract is used to treat
arterial occlusive disease, circulatory disorders, depression, free
radical deactivation, retinal lesions and edema, tinnitus, vertigo,
and to improve memory and mental concentration. Ginkgo seed is used
to treat asthma, chronic cough, leukorrhea and frequency of urination.
1) Ginkgo leaves contain flavonoids and the terpenoids which
combine with free radicals and can be classified as antioxidants.
Since it is believed that the free radicals are unstable molecules
playing a role in aging, cancer, and Alzheimer's disease. Europeans
use ginkgo extract to treat "cerebral insufficiency."
Although results of studies have been mixed, many still suggested
to use for memory problems, tinnitus, and depression.
A published study in the 1977 Journal of the American Medical Association
(JAMA) shown a study group of Alzheimer's disease taking ginkgo
showed modest, but very definite signs of improvement. The study
was done by giving standardized extract to hundreds of patients
who were suffered from dementia for six months to a year, while
a control group received placebo.
2) The other trails claim the ginkgo can improve Reynaud's
syndrome, intermittent claudication and erectile dysfunction. The
evidence for all these claims is much less substantial than for
the improvements seen in the patients with dementia.
3) The other laboratory studies suggest that ginkgo extract
may be useful in preventing contact dermatitis; help HIV patients
protect from recurrent pneumocystis carinii infection; heal chronic
venous ulcers; and may prevent some of the cellular changes associated
with aging.
4) The seed demonstrated anti-bacterial, anti-fungal and
anti-mycobacterial effects.
Concerns
Ginkgo extract can cause mild gastrointestinal
symptoms, headache, and occasionally allergic reactions. In 1991,
a German drug company surveyed nearly 11,000 people with dementia
who had used their ginkgo extract. Side effects were reported in
fewer than 2%, and all of those effects were minor and transient.
European ginkgo extracts are standardized --containing 22-27 percent
flavonoids and 5-7 percent terpenoids. That is not always the case
with ginkgo supplements made in United States. Users should read
the label for the appropriated concentration. Gingko seed also is
mildly toxic. The symptoms may occur after 1-12 hours after taking.
The menifestations are various from abdominal pain, diarrhea to
central nervous system excitation or depression. Now, one can see
a super-strength formulations of ginkgo are not necessarily a good
thing.
Precautions
One of the terpenoid compounds found
in ginkgo extracts interferes the blood clotting mechanism. Brain
hemorrhage in ginkgo users, one individual was taken coumadin and
another was taking aspirin (both are blood thinner) were reported.
This adverse effect probably would not be a consequence to normal
person, but anyone taking blood thinners (coumadin, heparin, etc.).
Ingested large amount of gingko seeds can induce convulsions and
coma as intoxicate effects.
Dosage
: In more than 30 different European
clinical trials the total dose of EGB 761 has ranged from 120-240
mg per day in divided doses. 6-9 gm daily for gingko seeds.
Summary
Ginkgo is a herb can be use medically
with its leaf or seed. The extracts from leaves could produce mild
improvements in patients with memory impairment problems such as
Alzheimer's disease. It had certain value in treating circulatory
disorders, such as erectile dysfunction. Since it contains substances
which interfere the clotting mechanism, thus it is not advice to
take together with blood thinners. The Gingko seed can treat chronic
cough and asthma.
Interesting Facts
Ginkgo seed is mentioned in Chinese
medical texts dating back more than 3,000 years. It has been used
as herb for treating lung trouble and as astringent for treating
leukorrhea and frequency of urination. Now, an extract of ginkgo
biloba, known as Egb 761, is very widely used in Europe to treat
"cerebral insufficiency." An annual sales over half a
billion dollars a year make it as the best selling herbal medication
in Europe.
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