What is the HPA axis and how that affected ejaculation control?

The Hypothalamus-Pituitary-Adrenal (HPA) axis is feedback-interaction system comprised of both the nervous and endocrine systems, which help control a man’s ejaculation mechanism. When the HPA axis is disrupted, typically in sexually exhausted men, it negatively affects the production of oxytocin and neurotransmitters that regulate the ejaculatory nerves and tissues, functions that if affect, can result in premature ejaculation.
Men's Premature Ejaculation
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