How excessive masturbation affected HPAT axis that resulted in poor sexual performance?

The hypothalamus-pituitary-adrenal-testicular (HPAT) is a synergic complex set of feedback interactions among nervous and endocrine systems that regulate many sexual functions and responses. Neurotransmitters and hormones are the major messengers that communicate within this neuroendocrine HPAT axis. This is the fundamental reason that when men masturbated excessively depleting neurotransmitters, they also exhibited various discomfort symptoms beyond sex organs.
Men's Over Masturbation
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